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T Cells Promote Liver Regeneration?

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Yale Article (Editorial)
Do Natural T Cells Promote Liver Regeneration?

I. Nicholas Crispe, M.B., B.S., Ph.D.
Immunobiology Section and Yale Liver Center
Yale University School of Medicine
New Haven, CT 


Abbreviations: TCR, T-cell receptor; NK, natural killer; NK-T, NK-like alpha-beta T cells.


Received February 14, 2000; accepted February 15, 2000.

From the Immunobiology Section and Yale Liver Center, Yale University School of Medicine, 310 Cedar Street, New Haven, CT.



1.  MacDonald HR. NK1.1+ T cell receptor alpha-beta cells: new clues to their origin, specificity and function. J Exp Med 1995;182:633-638 [Medline]. 
2.  Crispe IN, Mehal WZ. Strange brew: T cells in the liver. Immunol Today 1996;17:522-525 [Medline]. 
3.  Grant EP, Degano M, Rosat JP, Stenger S, Modlin RL, Wilson IA, Brenner MB. Molecular recognition of lipid antigens by T cell receptors. J Exp Med 1999;189:195-205 [Abstract/Full Text]. 
4.  Porcelli SA, Segelke BW, Sugita M, Wilson IA, Brenner MB. The CD1 family of lipid antigen-presenting molecules. Immunol Today 1998;19:362-368 [Medline]. 
5.  Sugita M, Moody DB, Jackman RM, Grant EP, Rosat JP, Behar SM, Peters PJ, et al. CD1a new paradigm for antigen presentation and T cell activation. Clin Immunol Immunopathol 1998;87:8-14 [Medline]. 
6.  Porcelli SA, Modlin RL. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Ann Rev Immunol 1999;17:297-329 [Abstract/Full Text]. 
7.  Bendelac A, Hunziker RD, Lantz O. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J Exp Med 1996;184:1285-1293 [Abstract]. 
8.  Vicari AP, Mocci S, Openshaw P, O'Garra A, Zlotnik A. Mouse gamma delta TCR+NK1.1+ thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to alpha beta TCR+NK1.1+ thymocytes. Eur J Immunol 1996;26:1424-1429 [Medline]. 
9.  Dao T, Mehal WZ, Crispe IN. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. J Immunol 1998;161:2217-2222 [Medline]. 
10.  Asarnow DM, Kuziel WA, Bonyhadi M, Tigelaar RE, Tucker PW, Allison JP. Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell 1998;55:837-847 [Medline]. 
11.  Havran WL, Chien Y-H, Allison JP. Recognition of self antigens by skin-derived T cells with invariant gamma antigen receptors. Science 1991;252:1430-1432 [Medline]. 
12.  Boismenu R, Havran W. Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science 1994;266:1253-1255 [Medline]. 
13.  Roberts SJ, Smith AL, West AB, Wen L, Findly RC, Owen MJ. T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci U S A 1996;93:11774-11779 [Abstract]. 
14.  D'Souza CD, Cooper AM, Frank AA, Mazzaccaro RJ, Bloom BR. An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J Immunol 1997;158:1217-1221 [Medline]. 
15.  King DP, Hyde DM, Jackson KA, Novosad DM, Ellis TN, Putney L, Stovall MY, et al. Cutting edge: protective response to pulmonary injury requires gamma delta T lymphocytes. J Immunol 1999;162:5033-5036 [Medline]. 
16.  Galant SP, Underwood SB, Lundak TC, Groncy CC, Mouratides DI. Heterogeneity of human lymphocyte subpopulations to pharmacologic stimulation. I. Lymphocyte responsiveness to beta adrenergic agents. J Allergy Clin Immunol 1978;62:349-356 [Medline]. 
17.  Felsner P, Hofer D, Rinner I, Porta S, Korsatko W, Schauenstein K. Adrenergic suppression of peripheral blood T cell reactivity in the rat is due to activation of peripheral alpha 2-receptors. J Neuroimm 1995;57:27-34 [Medline]. 
18.  Feldman RD, Hunninghake GW, McArdle WL. Beta-adrenergic-receptor-mediated suppression of interleukin 2 receptors in human lymphocytes. J Immunol 1987;139:3355-3359 [Medline]. 
19.  Okuyama R, Abo T, Seki S, Ohteki T, Sugiura K, Kusumi A, Kumagai K. Estrogen administration activates extrathymic T cell differentiation in the liver. J Exp Med 1992;175:661-669 [Abstract]. 
20.  Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992;356:314-317 [Medline]. 
21.  Dhein J, Daniel PT, Trauth BC, Oehm A, Moller P, Krammer PH. Induction of apoptosis by monoclonal antibody anti-Apo-1 class switch variants is dependent on cross-linking of Apo-1 cell surface antigens. J Immunol 1992;149:3166-3173 [Medline]. 
22.  Ni R, Tomita Y, Matsuda K, Ichihara A, Ishimura K, Ogasawara J, Nagata S. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res 1994;215:332-337 [Medline]. 
23.  Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL, Flavell RA. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A 1998;95:13618-13623 [Abstract/Full Text]. 
24.  Alderson MR, Armitage RL, Marakovsky E, Tough TW, Roux E, Schooley K, Ramsdell F, Lynch DH. Fas transduces activation signals in normal human T lymphocytes. J Exp Med 1993;178:2231-2235 [Abstract]. 
25.  Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998;8:615-623[Medline]. 
26.  Cruise JL, Knechtle SJ, Bollinger RR, Kuhn C. Alpha 1-adrenergic effects and liver regeneration. HEPATOLOGY 1987;7:1189-1194[Abstract]. 
27.  Tsai WH, Cruise JL, Michalopoulos GK. Blockade of alpha-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters. Carcinogenesis 1989;10:73-78[Abstract]. 
28.  Broten J, Michalopoulos G, Petersen B, Cruise J. Adrenergic stimulation of hepatocyte growth factor expression. Biochem Biophys Res Commun 1999;262:76-79[Medline]. 
29.  Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 1997;6:469-477[Medline]. 

Copyright © 2000 by the American Association for the Study of Liver Diseases.


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